Portuguese champion Benfica claimed a 2-1 home win over Marseille through goals by Rafa Silva and Argentine forward Angel Di Maria.
Benfica beat Marseille in the first leg of the Europa League quarter-final.
Rafa Silva gave the Portuguese hosts the lead after controlling Casper Tengstedt's pass before sweeping in.
Angel di Maria doubled their lead from David Neres' ball to finish off a fine move.
But Pierre-Emerick Aubameyang gave Marseille, who are eighth in Ligue 1, hope going into next week's second leg in France as he raced on to a through ball before firing home.
Former Benfica boss Sven-Goran Eriksson, who has cancer, was given a guard of honour on their pitch at half-time.
The winners of the tie face either Liverpool or Atalanta in the semi-finals. Atalanta won the first leg 3-0 at Anfield.
